Designing an integrated blood plasma supply chain under uncertainty demand of both therapy and medicine

Document Type : Research Paper


School of Industrial Engineering, Iran University of Science and Technology, Tehran, Iran


Blood plasma is a yellowish liquid component of blood that holds the blood cells (red blood cells, white blood cells, and platelets) in whole blood in suspension. Plasma is human-based so that it just makes in the body thus only donors can be the source for preparing plasma. Plasma has usage in two-part therapy and medicine. This article addresses the design of an integrated blood plasma supply chain network considering demand in two segments of therapy and medicine. To this goal, a MILP scenario-based mathematical programming model is developed which minimizes the total cost as well as the unsatisfied demand. After that, the actual data of a case study are used to illustrate the applicability also the performance of the offered model as well as validation. The obtained results show the superiority of the recovered plasma method compared to the apheresis plasma method for the blood transmission network. As well, the maximum use of the capacity instantly after the opening of each collection centers is beneficial for reducing the total cost.


Main Subjects

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Volume 12, Issue 4 - Serial Number 4
November 2019
Pages 252-268
  • Receive Date: 08 January 2020
  • Revise Date: 18 March 2020
  • Accept Date: 22 March 2020
  • First Publish Date: 27 July 2020