TY - JOUR ID - 43332 TI - Integrated planning for blood platelet production: a robust optimization approach JO - Journal of Industrial and Systems Engineering JA - JISE LA - en SN - 1735-8272 AU - Cheraghi, Sara AU - Hosseini-Motlagh, Seyyed-Mahdi AU - Ghatreh Samani, Mohammadreza AD - School of Industrial Engineering, Iran University of Science & Technology AD - School of Industrial Engineering, Iran University of Science & Technology, Tehran, Iran AD - School of Industrial Engineering, Iran University of Science &Technology Y1 - 2017 PY - 2017 VL - 10 IS - special issue on healthcare SP - 55 EP - 80 KW - Blood supply chains KW - Healthcare KW - Platelet-Rich Plasma KW - Buffy Coat KW - robust optimization DO - N2 - Perishability of blood products as well as uncertainty in demand amounts complicate the management of blood supply for blood centers. This paper addresses a mixed-integer linear programming model for blood platelets production planning while integrating the processes of blood collection as well as production/testing, inventory control and distribution. Whole blood-derived production methods for blood platelets (i.e., buffy coat and platelet-rich plasma methods) are particularly focused in our research. The problem is tackled with the aim of minimizing the supply chain total cost. To capture inherent uncertainty of input data, a robust programming approach is devised. A set of numerical experiments is carried out to evaluate the performance of the proposed model and the solution technique. Thereto, we employ two criteria: the mean and standard deviation of constraint violations under a number of random realizations to measure the quality of solutions achieved by both the proposed deterministic and robust models. Finally, several sensitivity analyses are accomplished to provide valuable managerial insights. The results imply the domination of robust approach over the deterministic one. UR - https://www.jise.ir/article_43332.html L1 - https://www.jise.ir/article_43332_1cd4d816a396d059e1900df565cae72e.pdf ER -