Iranian Institute of Industrial Engineering Journal of Industrial and Systems Engineering 1735-8272 8 2 2015 05 01 A new mathematical model for intensity matrix decomposition using multileaf collimator 13 29 8741 EN Vahid Mahmoodian Department of Industrial Engineering, Iran University of Science and Technology, Narmak, Tehran, Iran Ahmad Makui Department of Industrial Engineering, Iran University of Science and Technology, Narmak, Tehran, Iran 0000-0001-6249-530X Mohammad Reza Gholamian Department of Industrial Engineering, Iran University of Science and Technology, Narmak, Tehran, Iran 0000-0002-5135-5237 Journal Article 2015 01 10 Cancer is one of the major causes of death all over the globe and radiotherapy is considered one of its most effective treatment methods. Designing a radiotherapy treatment plan was done entirely manually in the past. RecentlyIntensity Modulated Radiation Therapy (IMRT) was introduced as a new technology with advanced medical equipmentin the recent years. IMRT provides the opportunity to deliver complex dose distributions to cancer cells while sparing the vital tissues and cells from the harmful effects of the radiations. Designing an IMRT treatment plan is a very complex matter due to the numerous calculations and parameters which must be decided for. Such treatment plan is designed in three separate phases: 1) selecting the number and the angle of the beams 2) extracting the intensity matrix or the corresponding dose map of each beam and 3) realizing each intensity matrix. The third phase has been studied in this research and a nonlinear mathematical model has been proposed for multileaf collimators. The proposed model has been linearized through two methods and an algorithm has been developed on its basis in order to solve the model with cardinality objective function. Obtained results are then compared with similar studies in the literature which reveals the capability of proposed method. https://www.jise.ir/article_8741_a35d11c2f995c60b0341a9c777f1ae03.pdf